CCACBWA Announces Publication of Groundbreaking Cyanide Antidote Research in Toxicology and Applied Pharmacology(IF: 3.6)

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The Center for Countermeasures Against Chemical and Biological Warfare Agents (CCACBWA) is proud to announce the publication of its landmark research on Sodasulphanecobalamin (SSC) , a novel cobalt‑sulfur complex that provides rapid cyanide detoxification and hemodynamic rescue in a rat model of acute cyanide poisoning. The study has been accepted for publication in the prestigious journal Toxicology and Applied Pharmacology. About the Research Cyanide poisoning remains a critical medical emergency, with high lethality occurring within minutes of exposure. Current antidotes such as hydroxocobalamin and nitrite‑thiosulfate therapy have significant limitations, including delayed onset, methemoglobinemia, or the need for multiple agents. Sodasulphanecobalamin (SSC) addresses these challenges through a dual‑action mechanism: Cobalt‑mediated chelation: Rapidly binds free cyanide ions to form non‑toxic complexes Sulfur‑donor detoxification: Converts cyanide to thiocyanate (SCN⁻) for renal elimination Key Findings Rapid action: Restored mean arterial pressure (MAP) within 5 ± 1 minutes – significantly faster than hydroxocobalamin (11 ± 2 min, p=0.032) and standard therapy (28 ± 3 min, p=0.0004) High efficacy: Achieved 100% survival at both 1.2× and 1.7× LD₅₀ of cyanide Delayed treatment: Maintained 100% survival even when administered 5 minutes after cyanide exposure Excellent safety: No clinical signs of toxicity, no hepatic or renal abnormalities, and no hematological disturbances over 28 days in naive rats Favorable PK: Terminal half‑life of 4.2 ± 0.6 hours, high plasma stability, and no detectable metabolites Significance for Chemical Defense This research addresses a critical gap in medical countermeasures for chemical threats. Current approaches require agent‑specific antidotes, complicating emergency response in mass casualty scenarios involving unknown or mixed exposures. SSC represents a significant step toward a single, rapid‑acting countermeasure for cyanide poisoning – a chemical warfare agent that remains a persistent threat to military and civilian populations. Next Steps The CCACBWA research team is now pursuing: Dose optimization studies Intramuscular administration evaluation for field use 90‑day GLP toxicology studies Structural determination by X‑ray crystallography Research Team This work was led by Olatunji N. Salako, Ph.D., in collaboration with: Ioannis Sarris (University of West Attica, Greece) Frank Anayo Orji (Federal Institute of Industrial Research, Nigeria) Vincent Chukuemaka Eze (Michael Okpara University of Agriculture, Nigeria) Kaliyapillai Vijayakumar (M. Kumarasamy College of Engineering, India) Prof. Levent Kenar (University of Health Sciences, Turkey) Access the Publication The full article is available online: 🔗 https://doi.org/10.1016/j.taap.2026.118027

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